Opdal Siri H, Rognum Torleiv O
Institute of Forensic Medicine, University of Oslo, Oslo, Norway.
Forensic Sci Med Pathol. 2011 Mar;7(1):26-36. doi: 10.1007/s12024-010-9182-9. Epub 2010 Jul 11.
Genetic risk factors play a role in sudden unexpected infant death; either as a cause of death, such as in cases with medium-chain acyl-coenzyme A dehydrogenase deficiency and cardiac arrest due to long QT syndrome, or as predisposing factors for sudden infant death syndrome (SIDS). Most likely genetic predisposition to SIDS represent a polygenic inheritance pattern leading to sudden death when combined with other risk factors, such as a vulnerable developmental stage of the central nervous system and/or the immune system, in addition to environmental risk factors, such as a common cold or prone sleeping position. Genes involved in the regulation of the immune system, cardiac function, the serotonergic network and brain function and development have so far emerged as the most important with respect to SIDS. The purpose of the present paper is to survey current knowledge on SIDS and possible genetic contributions.
遗传风险因素在婴儿猝死综合征中起作用；要么作为死因，如中链酰基辅酶A脱氢酶缺乏症和长QT综合征导致的心脏骤停病例，要么作为婴儿猝死综合征（SIDS）的易感因素。SIDS最可能的遗传易感性代表一种多基因遗传模式，当与其他风险因素（如中枢神经系统和/或免疫系统的脆弱发育阶段）以及环境风险因素（如普通感冒或俯卧睡眠姿势）相结合时，会导致猝死。迄今为止，参与免疫系统调节、心脏功能、血清素能网络以及脑功能和发育的基因在SIDS方面已被证明是最重要的。本文的目的是综述关于SIDS和可能的遗传贡献的当前知识。
