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本文引用的文献

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Intestinal Microbiota Composition in Sudden Infant Death Syndrome and Age-Matched Controls.婴儿猝死综合征与年龄匹配对照组的肠道微生物群组成
J Pediatr. 2017 Dec;191:63-68.e1. doi: 10.1016/j.jpeds.2017.08.070.
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How colonization by microbiota in early life shapes the immune system.生命早期微生物群的定殖如何塑造免疫系统。
Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378.
3
[Immunohistochemical investigations on pulmonary tissue in cases of sudden infant death syndrome (SIDS)].
Arch Kriminol. 2016 Jan-Feb;237(1-2):47-60.
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The Microbiome and the Respiratory Tract.微生物群与呼吸道
Annu Rev Physiol. 2016;78:481-504. doi: 10.1146/annurev-physiol-021115-105238. Epub 2015 Nov 2.
5
Brain weight in sudden unexpected death in infancy: experience from a large single-centre cohort.婴儿猝死综合征中的脑重量:来自一个大型单中心队列的经验
Neuropathol Appl Neurobiol. 2016 Jun;42(4):344-51. doi: 10.1111/nan.12251. Epub 2015 Jul 7.
6
Gut Microbiota and Immunity: Possible Role in Sudden Infant Death Syndrome.肠道微生物群与免疫:在婴儿猝死综合征中的可能作用
Front Immunol. 2015 Jun 3;6:269. doi: 10.3389/fimmu.2015.00269. eCollection 2015.
7
Exploring the risk factors for sudden infant deaths and their role in inflammatory responses to infection.探讨婴儿猝死的风险因素及其在感染炎症反应中的作用。
Front Immunol. 2015 Mar 5;6:44. doi: 10.3389/fimmu.2015.00044. eCollection 2015.
8
Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability.婴儿不明原因猝死中的齿状回异常:潜在脑易损性的形态学标志物。
Acta Neuropathol. 2015 Jan;129(1):65-80. doi: 10.1007/s00401-014-1357-0. Epub 2014 Nov 25.
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Immunohistochemical expression of inflammatory markers in sudden infant death; ancillary tests for identification of infection.
J Clin Pathol. 2014 Dec;67(12):1044-51. doi: 10.1136/jclinpath-2014-202489. Epub 2014 Oct 3.
10
α-Haemolysin of Escherichia coli in IBD: a potentiator of inflammatory activity in the colon.大肠杆菌α-溶血素在炎症性肠病中的作用:增强结肠炎症活性。
Gut. 2014 Dec;63(12):1893-901. doi: 10.1136/gutjnl-2013-306099. Epub 2014 Feb 17.

感染:婴儿猝死综合征研究中被忽视的范式。

Infection: the neglected paradigm in SIDS research.

作者信息

Goldwater Paul Nathan

出版信息

Arch Dis Child. 2017 Aug;102(8):767-772. doi: 10.1136/archdischild-2016-312327. Epub 2017 Jan 23.

DOI:10.1136/archdischild-2016-312327
PMID:28115322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5537520/
Abstract

Despite decades of investigation and millions of dollars spent, the cause of sudden infant death syndrome (SIDS) eludes researchers. It is timely therefore to reconsider the reasons for this failure and to explore how research might go forward with better prospects. This review assesses SIDS research in the context of clinicopathological and epidemiological features and determines that only infection attains congruence.

摘要

尽管经过了数十年的研究,花费了数百万美元,但婴儿猝死综合征(SIDS)的病因仍让研究人员捉摸不透。因此,现在是时候重新审视研究失败的原因,并探索如何让研究有更好的前景向前推进了。这篇综述在临床病理和流行病学特征的背景下评估了SIDS研究,并确定只有感染与之相符。