California NanoSystems Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
Small. 2010 Aug 16;6(16):1794-805. doi: 10.1002/smll.201000538.
Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug-delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin-loaded MSNs. These results indicate that MSNs are biocompatible, preferentially accumulate in tumors, and effectively deliver drugs to the tumors and suppress tumor growth.
介孔硅纳米颗粒（MSNs）是一种很有前途的药物传递材料。在这篇全文中，首先通过对注射 MSN 后血液样本和小鼠组织的血清学、血液学和组织病理学检查，证明 MSN 具有良好的耐受性。使用人源肿瘤异种移植进行的生物分布研究，结合体内成像和荧光显微镜成像以及电感耦合等离子体质谱进行。结果表明，MSNs 优先聚集在肿瘤中。最后，通过观察载喜树碱的 MSNs 处理的小鼠的肿瘤生长情况，证明了 MSNs 的药物传递能力。这些结果表明，MSNs 具有良好的生物相容性，优先聚集在肿瘤中，并能有效地将药物递送到肿瘤中并抑制肿瘤生长。
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