二氧化硅纳米颗粒作为基于核酸的试剂的递送系统。
Silica nanoparticles as a delivery system for nucleic acid-based reagents.
作者信息
Hom Christopher, Lu Jie, Tamanoi Fuyuhiko
机构信息
Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, 609 Charles E. Young Drive East, Los Angeles, CA, 90095, USA.
出版信息
J Mater Chem. 2009 Jan 1;19(35):6308-6316. doi: 10.1039/b904197d.
Abstract
The transport of nucleic acid-based reagents is predicated upon developing structurally stable delivery systems that can preferentially bind and protect DNA and RNA, and release their cargo upon reaching their designated sites. Recent advancements in tailoring the size, shape, and external surface functionalization of silica materials have led to increased biocompatibility and efficiency of delivery. In this Feature Article, we highlight recent research progress in the use of silica nanoparticles as a delivery vehicle for nucleic acid-based reagents.
摘要
基于核酸的试剂的运输取决于开发结构稳定的递送系统，该系统能够优先结合并保护DNA和RNA，并在到达指定位点时释放其所载物质。在定制二氧化硅材料的尺寸、形状和外表面功能化方面的最新进展已提高了生物相容性和递送效率。在这篇专题文章中，我们重点介绍了使用二氧化硅纳米颗粒作为基于核酸的试剂的递送载体的最新研究进展。
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