Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway.
Acta Paediatr. 2011 Jan;100(1):47-52. doi: 10.1111/j.1651-2227.2010.01946.x.
To investigate the effect of supplementation with docosahexaenoic acid (DHA) and arachidonic acid (AA) in early neonatal life on cognitive functions among human milk fed very low birth weight infants (<1500 g) at 20 months chronological age.
Randomized, double-blinded, placebo-controlled intervention supplementing human milk with 0.5 mL oil (containing 32 mg DHA and 31 mg AA or placebo) per 100 mL milk from 1 week after birth until discharge from hospital (9 weeks on average). The intervention and control group included 44 and 48 children, respectively. Attention capacity was evaluated by two 'free-play' sessions. General cognitive functions were evaluated by the Bayley Mental Development Index (MDI) and an Ages and Stages Questionnaire.
The results from the free-play sessions suggested positive effects from supplementation on functions related to attention. Neither the Bayley MDI nor the Ages and Stages Questionnaire showed significant difference between the intervention and control group. Plasma DHA concentration at discharge was positively correlated with both 'Sustained Attention' and the Bayley MDI according to chronological age.
A positive effect of early supplementation with DHA and AA on 20 months attention capacity was indicated. These findings need further investigation.
研究在生命早期补充二十二碳六烯酸（DHA）和花生四烯酸（AA）对人乳喂养的极低出生体重儿（<1500 克）在 20 个月龄时认知功能的影响。
随机、双盲、安慰剂对照干预，从出生后 1 周开始，每 100 毫升人乳添加 0.5 毫升油（含 32 毫克 DHA 和 31 毫克 AA 或安慰剂），直至出院（平均 9 周）。干预组和对照组分别有 44 名和 48 名儿童。通过两次“自由游戏”评估注意力容量。采用贝利心理发育指数（MDI）和年龄与阶段问卷评估一般认知功能。
自由游戏的结果表明，补充 DHA 和 AA 对与注意力相关的功能有积极影响。贝利 MDI 和年龄与阶段问卷均未显示干预组和对照组之间有显著差异。根据实际年龄，出院时的血浆 DHA 浓度与“持续注意力”和贝利 MDI 呈正相关。
早期补充 DHA 和 AA 对 20 个月龄的注意力有积极影响。这些发现需要进一步研究。
