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肌联蛋白在肌节结构和弹性中的作用。

Roles of titin in the structure and elasticity of the sarcomere.

作者信息

Tskhovrebova Larissa, Trinick John

机构信息

Institute for Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.

出版信息

J Biomed Biotechnol. 2010;2010:612482. doi: 10.1155/2010/612482. Epub 2010 Jun 21.

DOI:10.1155/2010/612482
PMID:20625501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2896707/
Abstract

The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.

摘要

巨大的肌联蛋白被认为在肌肉肌节的组装和功能中起主要作用。结构细节，如Z线和M线的宽度以及粗肌丝中的周期性，与肌联蛋白分子各个区域的亚结构相关。肌节的静息长度、其长度的工作范围以及被动弹性特性也直接受肌联蛋白特性的控制。在这里，我们回顾一些最近关于肌联蛋白的数据，并讨论其对肌节结构和弹性的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9524/2896707/aa6de8997639/JBB2010-612482.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9524/2896707/51e354e1197e/JBB2010-612482.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9524/2896707/aa6de8997639/JBB2010-612482.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9524/2896707/51e354e1197e/JBB2010-612482.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9524/2896707/aa6de8997639/JBB2010-612482.002.jpg

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