Carlberg Carsten, Seuter Sabine
Life Sciences Research Unit, University of Luxembourg, Luxembourg.
Chromosoma. 2010 Oct;119(5):479-84. doi: 10.1007/s00412-010-0283-8. Epub 2010 Jul 13.
Ligand-regulated nuclear receptors, such as estrogen receptors, glucocorticoid receptor, vitamin D receptor, and peroxisome proliferator-activated receptors, belong to the most widely studied and best understood transcription factors. Therefore, the dynamic nature of transcriptional regulation was observed first with different members of the nuclear receptor superfamily, but is now also extended to other transcription factors, such as nuclear factor κB. Dynamic and in part cyclical processes were observed on the level of translocation into the nucleus, association with genomic binding sites, exchange of co-regulators and chromatin modifiers, occurrence of chromatin marks, and activities of RNA polymerase II resulting in mRNA synthesis. In this review, we summarize recent findings on the dynamic regulation of nuclear receptor target genes in the chromatin context.
配体调节的核受体，如雌激素受体、糖皮质激素受体、维生素D受体和过氧化物酶体增殖物激活受体，属于研究最广泛且理解最深入的转录因子。因此，转录调控的动态特性最初是在核受体超家族的不同成员中观察到的，但现在也扩展到了其他转录因子，如核因子κB。在核转位、与基因组结合位点的结合、共调节因子和染色质修饰因子的交换、染色质标记的出现以及导致mRNA合成的RNA聚合酶II的活性等水平上观察到了动态且部分呈周期性的过程。在本综述中，我们总结了在染色质背景下核受体靶基因动态调控的最新研究发现。
