Hager Gordon L, McNally James G, Misteli Tom
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mol Cell. 2009 Sep 24;35(6):741-53. doi: 10.1016/j.molcel.2009.09.005.
All aspects of transcription and its regulation involve dynamic events. The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of transcription factors with chromatin--and with each other--play a key role in RNA polymerase assembly, initiation, and elongation. These short-term binding dynamics of transcription factors are superimposed by long-term cyclical behavior of chromatin opening and transcription factor-binding events. Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development.
转录及其调控的各个方面都涉及动态事件。基础转录机制和调控元件会动态地募集到它们的靶基因上，转录因子与染色质之间以及它们彼此之间的动态相互作用在RNA聚合酶的组装、起始和延伸过程中发挥关键作用。转录因子的这些短期结合动态受到染色质开放和转录因子结合事件的长期周期性行为的叠加影响。其动态特性不仅是转录机制的基本属性，而且正逐渐成为生理过程的重要调节因子，尤其是在分化和发育过程中。
