Endocrinology Department, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Gynecol Endocrinol. 2011 Jul;27(7):491-5. doi: 10.3109/09513590.2010.501874. Epub 2010 Jul 13.
Our aim was to evaluate C-reactive protein (CRP) and serum vaspin levels in women with polycystic ovary syndrome (PCOS) or polycystic ovaries (PCO).
Twenty-four women with PCOS and 23 women with PCO constituted the study groups. The control group comprised 24 healthy women.
Homeostatic model assessment for insulin resistance (HOMA-IR), CRP and serum vaspin levels were measured. The receiver-operating characteristic curve (ROC) of vaspin for prediction of women with increased diabetogenic risk was constructed.
The three groups did not significantly differ in age and body mass index. HOMA-IR was significantly higher in the PCOS and PCO groups than in control group. Median CRP levels in the control, PCO and PCOS groups were 0.66, 1.28 and 3.2 mg/l, respectively (p = 0.0001). Women with PCOS had significantly higher serum vaspin levels than the healthy controls [3.52 ± 1.38 vs. 0.36 ± 0.19 ng/ml, p = 0.0001]. Serum vaspin could differentiate between women with and without increased diabetogenic risk at a cut-off value of 1.82 ng/ml with a sensitivity of 83.3% and a specificity of 66.1%.
The results of our study showed that the presence of the increased vaspin, CRP and higher HOMA-IR levels in women with PCOS and PCO could contribute to increased diabetogenic and atherogenic risk in these patients.
评估多囊卵巢综合征（PCOS）或多囊卵巢（PCO）妇女的 C 反应蛋白（CRP）和血清 vaspin 水平。
24 名 PCOS 妇女和 23 名 PCO 妇女为研究组，24 名健康妇女为对照组。
测量胰岛素抵抗的稳态模型评估（HOMA-IR）、CRP 和血清 vaspin 水平。构建 vaspin 对预测糖尿病风险增加的妇女的受试者工作特征曲线（ROC）。
三组在年龄和体重指数方面无显著差异。PCOS 和 PCO 组的 HOMA-IR 明显高于对照组。对照组、PCO 组和 PCOS 组的 CRP 中位数分别为 0.66、1.28 和 3.2mg/L（p=0.0001）。PCOS 妇女的血清 vaspin 水平明显高于健康对照组[3.52±1.38 vs. 0.36±0.19ng/ml，p=0.0001]。血清 vaspin 在截断值为 1.82ng/ml 时可区分具有和不具有增加的糖尿病风险的妇女，其敏感性为 83.3%，特异性为 66.1%。
我们的研究结果表明，PCOS 和 PCO 妇女中存在升高的 vaspin、CRP 和更高的 HOMA-IR 水平，可能导致这些患者的糖尿病和动脉粥样硬化风险增加。
