Chair and Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 84 Street, 60-569 Poznań, Poland.
Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Bukowska 70 Street, 60-812 Poznań, Poland.
Biomolecules. 2023 Mar 10;13(3):508. doi: 10.3390/biom13030508.
Vaspin, a molecule produced in visceral adipose tissue, seems to participate in the pathogenesis of metabolic disorders. The study aimed to determine the association of vaspin concentration with metabolic disorders in obese individuals. Forty obese patients and twenty normal-weight subjects underwent biochemical (fasting glucose, insulin, lipid profile, interleukin-6, hs-CRP, vaspin concentration), blood pressure, and anthropometric measurements. The HOMA-IR index was calculated. Serum vaspin concentrations in the obese group were significantly higher than in the control group (0.82 ± 0.62 vs. 0.43 ± 0.59; < 0.001). Among the entire population, vaspin concentration was positively correlated with body weight, BMI, WHR, and the percentage and mass of adipose tissue. Positive correlations between vaspin concentration and triglyceride level, insulin concentration, and HOMA-IR value were found. Vaspin concentration was positively correlated with hs-CRP and IL-6 levels. In obese patients, positive correlations between vaspin concentration and the percentage of adipose tissue and hs-CRP level were demonstrated. Logistic regression analysis showed that increased BMI was the biggest factor stimulating vaspin concentrations (OR = 8.5; 95% CI: 1.18-61.35; = 0.0338). An elevated vaspin level may imply its compensatory role against metabolic disorders in obese patients. Thus, vaspin appears to be a useful diagnostic parameter for new therapeutic approaches in obesity-related complications. Nevertheless, due to the small sample size, further studies are needed to confirm our results.
内脏脂肪组织中产生的 Vaspin 似乎参与了代谢紊乱的发病机制。本研究旨在确定 Vaspin 浓度与肥胖个体代谢紊乱的相关性。40 名肥胖患者和 20 名体重正常的受试者接受了生化（空腹血糖、胰岛素、血脂谱、白细胞介素-6、hs-CRP、Vaspin 浓度）、血压和人体测量学测量。计算了 HOMA-IR 指数。肥胖组血清 Vaspin 浓度明显高于对照组（0.82±0.62 对 0.43±0.59；<0.001）。在整个人群中，Vaspin 浓度与体重、BMI、WHR 以及脂肪组织的百分比和质量呈正相关。Vaspin 浓度与甘油三酯水平、胰岛素浓度和 HOMA-IR 值呈正相关。Vaspin 浓度与 hs-CRP 和 IL-6 水平呈正相关。在肥胖患者中，Vaspin 浓度与脂肪组织百分比和 hs-CRP 水平呈正相关。Logistic 回归分析显示，BMI 增加是刺激 Vaspin 浓度的最大因素（OR=8.5；95%CI：1.18-61.35；=0.0338）。升高的 Vaspin 水平可能暗示其在肥胖患者代谢紊乱中的代偿作用。因此，Vaspin 似乎是肥胖相关并发症新治疗方法的有用诊断参数。然而，由于样本量小，需要进一步的研究来证实我们的结果。
