Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Reprod Sci. 2021 Nov;28(11):3032-3050. doi: 10.1007/s43032-021-00709-w. Epub 2021 Sep 1.
A body of studies has examined the circulating concentration of adipokines including apelin, vapin, resistin, and chemerin in polycystic ovary syndrome (PCOS) patients. However, their findings have been inconclusive. Therefore, we systematically reviewed available studies to illuminate the overall circulating concentration of adipokines in PCOS subjects. Cochrane's Library, PubMed, Scopus, and ISI Web of Science databases were searched from the earliest available date up to April 2021 for relevant articles. The quality of each study was assessed by the Newcastle-Ottawa Quality Assessment Scale. The pooled effect size was estimated based on the random effects model, and the standard mean differences (SMD) with a 95% confidence interval (CI) were reported. A total of 88 studies met the inclusion criteria and were included in the current systematic review and meta-analysis. The results of the analysis showed that serum levels of vaspin (SMD 0.69; 95% CI, 0.22 to 1.17; P = 0.004; I = 90.6%), chemerin (SMD 1.87; 95% CI, 1.35 to 2.40; P < 0.001; I = 94.4%), and resistin (SMD 0.66; 95% CI, 0.41 to 0.91; P < 0.001; I = 92.6%) were significantly higher in the PCOS group compared to controls. However, there was no significant difference between the PCOS and control groups in relation to apelin levels (SMD - 0.17; 95% CI, - 1.06 to 0.73; P = 0.714; I = 97.8%). We found that serum levels of vaspin, chemerin, and resistin were significantly higher in PCOS subjects compared with controls. It seems that these adipokines can be measured as a useful marker to predict the development of PCOS.
已有大量研究探讨了多囊卵巢综合征（PCOS）患者循环脂肪因子（包括脂联素、内脂素、抵抗素和趋化素）的浓度。然而，这些研究结果尚无定论。因此，我们系统性地回顾了现有的研究，以阐明 PCOS 患者循环脂肪因子的总体浓度。我们从最早的可用日期到 2021 年 4 月，在 Cochrane 图书馆、PubMed、Scopus 和 ISI Web of Science 数据库中搜索了相关文章。我们使用纽卡斯尔-渥太华质量评估量表评估了每项研究的质量。我们基于随机效应模型估计合并效应大小，并报告了标准均数差（SMD）及其 95%置信区间（CI）。共有 88 项研究符合纳入标准，并纳入了本系统评价和荟萃分析。分析结果表明，血清内脂素水平（SMD 0.69；95%CI，0.22 至 1.17；P=0.004；I=90.6%）、趋化素水平（SMD 1.87；95%CI，1.35 至 2.40；P<0.001；I=94.4%）和抵抗素水平（SMD 0.66；95%CI，0.41 至 0.91；P<0.001；I=92.6%）在 PCOS 组显著高于对照组。然而，在脂联素水平方面，PCOS 组与对照组之间没有显著差异（SMD -0.17；95%CI，-1.06 至 0.73；P=0.714；I=97.8%）。我们发现，与对照组相比，PCOS 患者的血清内脂素、趋化素和抵抗素水平显著升高。似乎这些脂肪因子可以作为预测 PCOS 发生的有用标志物进行测量。
