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[局部类肝素对预防隆鼻术后水肿和瘀斑的疗效]

[Efficacy of local heparinoids on preventing edema and ecchymosis after rhinoplasty].

作者信息

Kelleş Mehmet, Erdem Tamer, Fırat Yezdan, Kalcıoğlu M Tayyar, Akarçay Mustafa, Selimoğlu Erol, Yoloğlu Saim

机构信息

Inönü Universitesi Tip Fakültesi, Malatya, Turkey.

出版信息

Kulak Burun Bogaz Ihtis Derg. 2010 Jul-Aug;20(4):191-4.

Abstract

OBJECTIVES

In this study, the effect of local heparinoids on prevention of periorbital edema and ecchymosis due to rhinoplasty was investigated.

PATIENTS AND METHODS

Twenty patients (12 males, 8 females, mean age 23.3 years; range 19 to 34 years) who had bilateral osteotomy were randomly administered postoperative local heparinoid on one periorbital region, without performing any care in the other one. One and a half centimeter of heparinoid was applied once a day for nine days. The other periorbital region was used as control group. The heparinoid was applied additionally, 8 mg dexamethasone i.v was administered to all patients 30 minutes before the surgery and 24 hours after the surgery. Photographs of each patient which were taken on postoperative days 1, 3, 5 and 9 were evaluated as double-blind by two observers. Scoring was performed according to edema and ecchymosis scales.

RESULTS

There was no statistical difference with respect to edema and ecchymosis between local heparinoid treated and control eyes.

CONCLUSION

No hypersensitivity to drugs occurred in any patients. After analysing the scores, we observed that heparanoids administered locally was not effective in preventing periorbital edema and ecchymosis after rhinoplasty (p>0.05).

摘要

目的

本研究探讨局部使用类肝素对预防隆鼻术后眶周水肿和瘀斑的效果。

患者与方法

20例行双侧截骨术的患者(12例男性,8例女性,平均年龄23.3岁;年龄范围19至34岁),术后在一侧眶周区域随机给予局部类肝素,另一侧不进行任何处理。每天应用1.5厘米类肝素,共9天。另一侧眶周区域作为对照组。所有患者在手术前30分钟和手术后24小时额外静脉注射8毫克地塞米松。两名观察者对术后第1、3、5和9天拍摄的每位患者照片进行双盲评估。根据水肿和瘀斑量表进行评分。

结果

局部使用类肝素治疗的眼睛与对照眼睛在水肿和瘀斑方面无统计学差异。

结论

所有患者均未出现药物过敏反应。分析评分后,我们观察到局部应用类肝素对预防隆鼻术后眶周水肿和瘀斑无效(p>0.05)。

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