Jaffe N
Department of Pediatrics, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Pediatr Rev. 1991 May;12(11):333-43.
Osteosarcoma is principally a disease of the pre-teenager and teenage individual. Pain and swelling of an extremity are the usual initial symptoms. A number of neoplastic and nonneoplastic conditions must be considered in the differential diagnosis. Good quality radiographs complement pathologic material in establishing the diagnosis. Major advances as a consequence of chemotherapy have been achieved during the past decade. Disease-free survival following surgical ablation of the primary tumor and postoperative adjuvant chemotherapy is approximately 60%. The majority of patients undergoing modern forms of treatment are also candidates for limb salvage.
骨肉瘤主要是一种发生在青少年前期和青少年时期的疾病。肢体疼痛和肿胀是常见的初始症状。在鉴别诊断中必须考虑多种肿瘤性和非肿瘤性疾病。高质量的X线片在确立诊断方面可补充病理资料。在过去十年中，化疗取得了重大进展。原发性肿瘤手术切除及术后辅助化疗后的无病生存率约为60%。大多数接受现代治疗方式的患者也是保肢治疗的候选对象。
