Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
Blood Purif. 2010;30(2):84-8. doi: 10.1159/000318585. Epub 2010 Jul 13.
Extracorporeal removal techniques are effective methods for toxin removal from the body. To define the safety and clinical outcomes of hemoperfusion, we evaluated retrospectively clinical outcomes of hemoperfusion over a 3-year period in our clinical center. From January 2006 to December 2008, we analyzed 803 patients. Mortality, catheter-related bleeding, systemic bleeding, hypocalcemia, and thrombocytopenia were investigated. Medical drugs (n = 54) and pesticide toxins (n = 749) were represented. Pesticides included herbicides (n = 598), insecticides (n = 130), mixed herbicides and insecticides (n = 4), and unknown pesticides (n = 17). Among those with herbicide poisoning, 493 cases were caused by paraquat, and among those affected by insecticides, 67 cases were caused by organophosphate insecticides. After hemoperfusion, systemic bleeding complications were observed in 26 cases (3.0%). Systemic bleeding was a greater mortality risk factor than nonsystemic bleeding (OR 2.779, 95% CI 1.07-7.23). Hypocalcemia was observed in 69.1% and thrombocytopenia in 31.1%. Excess mortality was 44.4%. In hemoperfusion cases, systemic bleeding is a major factor to predict adverse outcome.
体外去除技术是从体内去除毒素的有效方法。为了定义血液灌流的安全性和临床结果，我们回顾性地评估了我们临床中心在 3 年期间的血液灌流的临床结果。从 2006 年 1 月至 2008 年 12 月，我们分析了 803 名患者。调查了死亡率、导管相关出血、全身出血、低钙血症和血小板减少症。代表了医疗药物（n = 54）和农药毒素（n = 749）。农药包括除草剂（n = 598）、杀虫剂（n = 130）、混合除草剂和杀虫剂（n = 4）和未知农药（n = 17）。在除草剂中毒的患者中，493 例由百草枯引起，在杀虫剂中毒的患者中，67 例由有机磷杀虫剂引起。血液灌流后，观察到 26 例（3.0%）全身出血并发症。全身出血是比非全身出血更大的死亡风险因素（OR 2.779，95%CI 1.07-7.23）。低钙血症发生率为 69.1%，血小板减少症发生率为 31.1%。过量死亡率为 44.4%。在血液灌流病例中，全身出血是预测不良预后的主要因素。
