Kant G J, Bauman R A, Pastel R H, Myatt C A, Closser-Gomez E, D'Angelo C P
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Physiol Behav. 1991 Mar;49(3):625-30. doi: 10.1016/0031-9384(91)90289-z.
The effects of sustained stress on body temperature were investigated in rats implanted with mini-transmitters that permitted remote measurement of body temperature. Temperature was first monitored during control conditions. Following the control period, rats were either shaped to avoid/escape signalled around-the-clock intermittent footshock (controllable stress) or yoked to the controlling rats such that the controlling rat and the yoked rat received shock of the same duration, but only the controlling rat could terminate shock by pulling a ceiling chain. Under control conditions, rats demonstrated regular rhythms in body temperature which averaged 1 degree higher during the 12-h dark cycle than the light cycle. Stress disrupted the rhythm and markedly decreased the night-day difference in temperature, especially in the yoked rats in which almost no difference between light and dark cycle temperature was seen. The disruption was most marked for the first days of stress. A regular temperature rhythm was reestablished following about 5 days of stress although the stress condition continued. Leverpressing for food was also affected by the stress conditions with both stress groups leverpressing less than controls and the uncontrollable stress group pressing less than the controllable stress group. These data offer additional evidence of the increased pathophysiological effects of uncontrollable as compared to controllable stress.
在植入了允许远程测量体温的微型发射器的大鼠中，研究了持续应激对体温的影响。首先在对照条件下监测体温。在对照期之后，大鼠要么被训练以避免/逃脱有信号提示的全天候间歇性足部电击（可控应激），要么与控制组大鼠配对，使得控制组大鼠和配对大鼠接受相同持续时间的电击，但只有控制组大鼠可以通过拉动天花板上的链条来终止电击。在对照条件下，大鼠表现出规律的体温节律，在12小时的黑暗周期中平均比光照周期高1度。应激扰乱了节律，并显著降低了昼夜体温差异，尤其是在配对大鼠中，光照和黑暗周期的体温几乎没有差异。这种扰乱在应激的最初几天最为明显。尽管应激条件持续存在，但在大约5天的应激后，重新建立了规律的体温节律。为获取食物而按压杠杆的行为也受到应激条件的影响，两个应激组按压杠杆的次数都少于对照组，且不可控应激组按压次数少于可控应激组。这些数据为不可控应激与可控应激相比病理生理效应增加提供了额外证据。
