Wijkstra S, Valkhof N, Koolhaas J M, Schuiling G A
Department of Obstetrics and Gynecology, University of Groningen, The Netherlands.
Physiol Behav. 1991 Mar;49(3):647-9. doi: 10.1016/0031-9384(91)90294-x.
The offspring of endotoxin-infused pregnant rats (0.2 micrograms endotoxin, 53.3 min, day 18 of pregnancy) did not exhibit different behavior in the Hebb-Williams-type maze test, but the males showed aberrations in the sexual behavior test. Because endotoxin did not cross the placental barrier, it was concluded that the effect reflects abnormal brain development, caused by endotoxin-induced placental malfunction, notably impaired oxygen transport.
给怀孕大鼠在孕期第18天注入内毒素（0.2微克内毒素，53.3分钟）后所产的后代，在赫布 - 威廉姆斯型迷宫测试中未表现出行为差异，但雄性后代在性行为测试中出现了异常。由于内毒素不会穿过胎盘屏障，因此得出结论，这种影响反映了由内毒素诱导的胎盘功能障碍（尤其是氧气运输受损）导致的大脑发育异常。
