Dwivedi Y, Rastogi R, Sharma S K, Garg N K, Dhawan B N
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Planta Med. 1991 Feb;57(1):25-8. doi: 10.1055/s-2006-960009.
Thioacetamide (100 mg/kg), when administered to normal rats, caused a significant increase in the activities of 5'-nucleotidase and gamma-glutamyl transpeptidase and a decrease in the activities of glucose 6-phosphatase and succinate dehydrogenase enzymes in the liver. DNA, RNA, and proteins were increased while the cytochrome P450 in the microsomal fraction and the glycogen content in the liver were decreased significantly. Elevations in the activities of GOT, GPT, and alkaline phosphatase and bilirubin content in serum were also observed. Picroliv, a standardised glycoside fraction of Picrorhiza kurroa, in doses of 12.5 and 25 mg/kg prevented most of the biochemical changes induced by thioacetamide in liver and serum. The hepatoprotective activity of Picroliv was comparable with that of silymarin, a known hepatoprotective agent obtained from seeds of Silybum marianum.
给正常大鼠施用硫代乙酰胺（100毫克/千克）后，肝脏中5'-核苷酸酶和γ-谷氨酰转肽酶的活性显著增加，而葡萄糖6-磷酸酶和琥珀酸脱氢酶的活性降低。DNA、RNA和蛋白质增加，而微粒体部分的细胞色素P450和肝脏中的糖原含量显著降低。血清中的谷草转氨酶、谷丙转氨酶和碱性磷酸酶活性以及胆红素含量也升高。胡黄连苷（Picroliv）是胡黄连（Picrorhiza kurroa）的标准化糖苷部分，剂量为12.5和25毫克/千克，可预防硫代乙酰胺在肝脏和血清中引起的大部分生化变化。胡黄连苷的肝脏保护活性与水飞蓟宾相当，水飞蓟宾是从水飞蓟（Silybum marianum）种子中获得的一种已知肝脏保护剂。
