Visen P K, Shukla B, Patnaik G K, Dhawan B N
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Planta Med. 1993 Feb;59(1):37-41. doi: 10.1055/s-2006-959600.
Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent.
苦味叶下珠素是从植物胡黄连中提取的标准化提取物，含有活性成分。在离体肝细胞（体外）制备物上评估发现，它对大鼠半乳糖胺诱导的肝损伤具有显著的剂量依赖性（口服3 - 12毫克/千克，共7天）保护活性。它显著提高了肝细胞的活力百分比。它还恢复了半乳糖胺诱导的分离肝细胞以及血清中酶（谷草转氨酶、谷丙转氨酶和碱性磷酸酶）水平的变化。此外，苦味叶下珠素具有显著的抗胆汁淤积作用。结果发现，苦味叶下珠素比标准保肝剂水飞蓟素更有效。
