Department of Urology, Kliniken Maria Hilf GmbH, Mönchengladbach, Germany.
Andrologia. 2010 Aug;42(4):218-24. doi: 10.1111/j.1439-0272.2009.00975.x.
Erectile dysfunction (ED) is often associated with cardiovascular disorders such as hypertension, coronary heart disease, hypercholesterolaemia and diabetes mellitus. The genotypes in the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms have been identified as genetic risk factors for cardiovascular disorders. The association between the genotypes in these polymorphisms and the risk to develop ED was analysed. In 455 German ED patients and 111 age-matched healthy controls genotyping in the candidate polymorphisms was performed after DNA extraction from whole blood. Association studies between the genotype distribution in the control group in comparison with the ED-group and age of onset of the disease as well as erectile response to intracorporal prostaglandin injection in dependence of candidate polymorphism genotype were performed using the SPSS-Software(R). Genotype distribution of the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms was similar in the ED population and the healthy control group. The age of onset of the disease as well as the erectile response to intracorporal prostaglandin injection was independent of the genotypes in the three candidate polymorphisms. In contrast to the previous studies in this analysis, the risk to develop ED is not influenced by the genotypes in the GNB3 C825T, the ACE I/D and the eNOS G894T polymorphisms.
勃起功能障碍（ED）通常与心血管疾病有关，如高血压、冠心病、高脂血症和糖尿病。已经确定 GNB3 C825T、ACE I/D 和 eNOS G894T 多态性中的基因型是心血管疾病的遗传危险因素。分析了这些多态性中的基因型与发生 ED 的风险之间的关系。在 455 名德国 ED 患者和 111 名年龄匹配的健康对照组中，从全血中提取 DNA 后，在候选多态性中进行基因分型。使用 SPSS 软件（R）进行候选多态性基因型与 ED 组相比对照组的基因型分布与疾病发病年龄以及依赖候选多态性基因型的体内前列腺素注射勃起反应之间的关联研究。ED 人群和健康对照组的 GNB3 C825T、ACE I/D 和 eNOS G894T 多态性的基因型分布相似。疾病发病年龄以及体内前列腺素注射勃起反应与三种候选多态性的基因型无关。与之前在该分析中的研究相反，发生 ED 的风险不受 GNB3 C825T、ACE I/D 和 eNOS G894T 多态性的基因型影响。
