Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Am J Mens Health. 2024 Sep-Oct;18(5):15579883241282385. doi: 10.1177/15579883241282385.
Accumulating evidence suggests a link between vascular endothelial growth factor (VEGF), erectile dysfunction (ED), and metabolic syndrome (Mets), possibly because VEGF can alter the physiological pathways involved in the regulation of endothelial cell proliferation. This study aimed to investigate the genetic susceptibility of VEGF 2578C>A polymorphism to the development of ED and Mets. Collected data included five-item International Index of Erectile Function (IIEF-5), components of Mets, and VEGF 2578C>A polymorphism. A total of 596 subjects from Kaohsiung with a mean age of 55.5 years were enrolled, data collection was done at our hospital. Individuals carrying the VEGF 2578 A allele (CA+AA genotypes) demonstrated a higher prevalence of ED compared to those with the CC genotype, with an adjusted odds ratio (OR) of 1.582 (95% confidence interval [95% CI] = 1.123-2.227, value = 0.009) in multivariate binary regression analysis. Similarly, individuals carrying the VEGF 2578 A allele showed a higher prevalence of Mets compared to those with the CC genotype, with an adjusted OR of 2.461 (95% CI = 1.491-4.064, value < 0.001). Furthermore, A allele carriers had significantly lower IIEF-5 scores and a higher number of Mets components compared to those with the C allele ( value < 0.001, respectively). In conclusion, VEGF 2578 A allele carriers are at a greater risk of both Mets and ED, suggesting that the VEGF 2578C>A polymorphism may serve as a common genetic susceptibility factor in the development of both disorders. Further research is warranted to evaluate the mechanisms underlying this association.
越来越多的证据表明血管内皮生长因子（VEGF）、勃起功能障碍（ED）和代谢综合征（Mets）之间存在关联，这可能是因为 VEGF 可以改变参与内皮细胞增殖调节的生理途径。本研究旨在探讨 VEGF 2578C>A 多态性对 ED 和 Mets 发展的遗传易感性。收集的数据包括国际勃起功能指数（IIEF-5）的五个项目、 Mets 的组成部分和 VEGF 2578C>A 多态性。共纳入高雄市 596 名平均年龄为 55.5 岁的个体，在我院进行数据收集。与 CC 基因型相比，携带 VEGF 2578 A 等位基因（CA+AA 基因型）的个体 ED 发生率更高，多变量二项回归分析调整后的优势比（OR）为 1.582（95%置信区间 [95%CI] = 1.123-2.227， 值=0.009）。同样，与 CC 基因型相比，携带 VEGF 2578 A 等位基因的个体 Mets 发生率更高，调整后的 OR 为 2.461（95%CI = 1.491-4.064， 值<0.001）。此外，与携带 C 等位基因的个体相比，A 等位基因携带者的 IIEF-5 评分明显更低， Mets 成分更多（ 值<0.001，分别）。总之，VEGF 2578 A 等位基因携带者患 Mets 和 ED 的风险更高，这表明 VEGF 2578C>A 多态性可能是这两种疾病发展的共同遗传易感性因素。需要进一步研究来评估这种关联的机制。
