Eisenhardt A, Sperling H, Rübben H
Praxisklinik Urologie Rhein Ruhr, Schulstr. 11, 45468, Mülheim an der Ruhr, Deutschland,
Urologe A. 2015 May;54(5):662-7. doi: 10.1007/s00120-015-3793-4.
Erectile dysfunction (ED) is a common disorder in man that influences the quality of life of the patient and his partner. Known risk factors for ED comprise diabetes, coronary artery disease, hypertension but also lifestyle modifications such as smoking, diminished physical activity as well as obesity. In this manuscript the current scientific literature about genetics and erectile dysfunction is reviewed.
A literature search using the databank PubMed covering the topics genetics and erectile dysfunction was performed and relevant papers selected for presentation.
Several aspects of genetics and ED are described in the current literature. Association studies of candidate polymorphisms and ED risk in comparison to healthy controls is a major area of research. Another topic is the genome-wide search for candidate polymorphisms with erectile dysfunction. The paper closes with the presentation of the pharmacogenomic analysis of treatment response to phosphodiesterase-5 inhibitors.
The heterogeneous results of genetic association studies are possibly due to small sample sizes of the study population and/or due to ethnic differences of the analyzed populations. This underlines the need for validation of this data in larger prospective multinational multicenter studies.
勃起功能障碍（ED）是男性常见疾病，会影响患者及其伴侣的生活质量。已知的ED风险因素包括糖尿病、冠状动脉疾病、高血压，以及吸烟、体力活动减少和肥胖等生活方式改变。本文对当前有关遗传学与勃起功能障碍的科学文献进行综述。
利用PubMed数据库进行文献检索，检索主题为遗传学与勃起功能障碍，并选择相关论文进行展示。
当前文献描述了遗传学与ED的几个方面。与健康对照相比，候选多态性与ED风险的关联研究是一个主要研究领域。另一个主题是全基因组搜索勃起功能障碍的候选多态性。本文最后介绍了对磷酸二酯酶-5抑制剂治疗反应的药物基因组学分析。
遗传关联研究结果的异质性可能是由于研究人群样本量小和/或所分析人群的种族差异。这突出表明需要在更大规模的前瞻性跨国多中心研究中验证这些数据。
