Loimer N, Schmid R, Grünberger J, Jagsch R, Linzmayer L, Presslich O
Allgemeines Krankenhaus der Stadt Wien, Psychiatrische Universitätsklinik, Vienna, Austria.
Psychopharmacology (Berl). 1991;103(4):538-40. doi: 10.1007/BF02244255.
In methadone maintenance therapy methadone plasma concentrations of 400 ng/ml are necessary to suppress any further opiate action and to provide stabilized maintenance. In a controlled study we have searched for a differentiation in autonomous activation between patients having low and high methadone plasma levels, using static and dynamic pupillometry and habituation of skin conductance response. Results show that there is no difference in psychophysiological response between patients with high (greater than 400 ng/ml) or low (less than 400 ng/ml) plasma levels of methadone. This indicates that there is no reduction in behavioral arousal in patients with high plasma methadone levels. On the basis of these findings, there is no rationale to maintain patients on plasma levels below 400 ng/ml.
在美沙酮维持治疗中，需要400纳克/毫升的美沙酮血浆浓度来抑制任何进一步的阿片类药物作用并提供稳定的维持治疗。在一项对照研究中，我们使用静态和动态瞳孔测量法以及皮肤电反应习惯化，来寻找美沙酮血浆水平高低不同的患者之间自主激活的差异。结果表明，美沙酮血浆水平高（大于400纳克/毫升）或低（小于400纳克/毫升）的患者之间在心理生理反应上没有差异。这表明美沙酮血浆水平高的患者的行为唤醒没有降低。基于这些发现，没有理由让患者维持在低于400纳克/毫升的血浆水平。
