• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.

作者信息

Liu S J, Wang R I

出版信息

Am J Psychiatry. 1984 Oct;141(10):1287-8. doi: 10.1176/ajp.141.10.1287.

DOI:10.1176/ajp.141.10.1287
PMID:6486271
Abstract

A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma methadone level must be monitored.

摘要

相似文献

1
Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.
Am J Psychiatry. 1984 Oct;141(10):1287-8. doi: 10.1176/ajp.141.10.1287.
2
A comparison of the withdrawal responses of heroin and methadone addicts during detoxification.海洛因成瘾者和接受美沙酮维持治疗者在戒毒期间戒断反应的比较。
Br J Psychiatry. 1991 May;158:697-9. doi: 10.1192/bjp.158.5.697.
3
Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.丙戊酸与其他抗惊厥药不同，对美沙酮代谢无影响：两例病例报告
J Clin Psychiatry. 1989 Jun;50(6):228-9.
4
Serum methadone as an aid in managing methadone maintenance patients.血清美沙酮在美沙酮维持治疗患者管理中的辅助作用。
Int J Addict. 1978 Jul;13(5):689-94. doi: 10.3109/10826087809039295.
5
Withdrawal from heroin and methadone.
Br J Psychiatry. 1991 Oct;159:582-3. doi: 10.1192/bjp.159.4.582.
6
Naltrexone-assisted rapid methadone discontinuation: a pilot study.纳曲酮辅助快速美沙酮脱毒：一项试点研究。
Eur Addict Res. 2007;13(1):20-4. doi: 10.1159/000095811.
7
[A case report on methadone withdrawal syndrome].[美沙酮戒断综合征病例报告]
Hu Li Za Zhi. 2009 Dec;56(6):95-100.
8
Rapid detoxification from opioid dependence under general anaesthesia versus standard methadone tapering: abstinence rates and withdrawal distress experiences.全身麻醉下从阿片类药物依赖中快速脱毒与标准美沙酮逐渐减量：戒断率和戒断痛苦经历
Addict Biol. 2003 Sep;8(3):351-8. doi: 10.1080/13556210310001602275.
9
Rifampin-induced methadone withdrawal.
N Engl J Med. 1976 May 13;294(20):1104-6. doi: 10.1056/NEJM197605132942008.
10
[Substance dependence and pregnancy. Experience in care].
Minerva Ginecol. 1986 Nov;38(11):895-902.

引用本文的文献

1
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.苯巴比妥治疗阿片类药物流行背景下的酒精戒断：一个被忽视的警告。
Addiction. 2023 Jul;118(7):1198-1200. doi: 10.1111/add.16194. Epub 2023 Apr 10.
2
Interindividual variability of methadone response: impact of genetic polymorphism.美沙酮反应的个体间差异：基因多态性的影响
Mol Diagn Ther. 2008;12(2):109-24. doi: 10.1007/BF03256276.
3
Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.
美沙酮临床药代动力学的个体间变异性：对阿片类药物依赖治疗的影响。
Clin Pharmacokinet. 2002;41(14):1153-93. doi: 10.2165/00003088-200241140-00003.
4
A single dose of methadone inhibits cytochrome P-4503A activity in healthy volunteers as assessed by the urinary cortisol ratio.通过尿皮质醇比率评估，单剂量美沙酮可抑制健康志愿者体内细胞色素P-4503A的活性。
Br J Clin Pharmacol. 2001 Apr;51(4):350-4. doi: 10.1046/j.1365-2125.2001.01360.x.
5
Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.人肝微粒体中美沙酮的N-去甲基化：缺乏立体选择性及细胞色素P450 3A4的参与
Br J Clin Pharmacol. 1999 Apr;47(4):403-12. doi: 10.1046/j.1365-2125.1999.00921.x.
6
Drug interactions of clinical significance with opioid analgesics.阿片类镇痛药具有临床意义的药物相互作用。
Drug Saf. 1993 Jan;8(1):30-48. doi: 10.2165/00002018-199308010-00005.
7
Steady-state pharmacokinetics of methadone in opioid addicts.
Eur J Clin Pharmacol. 1993;44(2):189-94. doi: 10.1007/BF00315479.
8
Antiepileptic drugs. A review of clinically significant drug interactions.抗癫痫药物。具有临床意义的药物相互作用综述。
Drug Saf. 1993 Sep;9(3):156-84. doi: 10.2165/00002018-199309030-00003.
9
Methadone maintenance in the treatment of opioid dependence. A current perspective.美沙酮维持疗法在阿片类药物依赖治疗中的应用：当前观点
West J Med. 1990 May;152(5):588-99.
10
Psychophysiological reactions in methadone maintenance patients do not correlate with methadone plasma levels.美沙酮维持治疗患者的心理生理反应与血浆美沙酮水平无关。
Psychopharmacology (Berl). 1991;103(4):538-40. doi: 10.1007/BF02244255.