School of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
J Endod. 2010 Jul;36(7):1174-8. doi: 10.1016/j.joen.2010.02.031. Epub 2010 Apr 24.
The aim of this study was to evaluate the subcutaneous connective tissue reaction to mineral trioxide aggregate (MTA)-based sealer (Endo CPM Sealer; CPM Sealer; EGEO SRL, Buenos Aires, Argentina), MTA, and an epoxy resin-based sealer (AH Plus; Dentsply HERO Indústria e Comércio Ltda, Petrópolis, RJ, Brazil).
Polyethylene tubes containing the test materials and empty tubes (control group) were implanted in the subcutaneous tissue of 18 rats. After 7, 30, and 60 days, observations were made for cellular inflammatory components, fibrous condensation, and abscess formation. Comparisons between groups and periods of time were made using the Friedman test and the Kruskall-Wallis test.
Lymphocytes and plasmacytes were more intensely observed in the reaction to AH Plus sealer after 30 days (p < 0.05). MTA and the Endo CPM Sealer presented a behavior similar to that of the control group throughout the whole experiment.
The Endo CPM Sealer presented biological potential. Characteristics of the inflammatory reaction were equivalent to those produced by MTA.
本研究旨在评估矿物三氧化物聚合体（MTA）基封闭剂（Endo CPM 封闭剂；CPM 封闭剂；EGEO SRL，布宜诺斯艾利斯，阿根廷）、MTA 和一种环氧树脂基封闭剂（AH Plus；Dentsply HERO Indústria e Comércio Ltda，Petrópolis，RJ，巴西）在皮下结缔组织中的反应。
将含有测试材料的聚乙烯管和空管（对照组）植入 18 只大鼠的皮下组织中。在第 7、30 和 60 天，观察细胞炎症成分、纤维凝结和脓肿形成情况。使用 Friedman 检验和 Kruskall-Wallis 检验比较各组和各时间段之间的差异。
在第 30 天时，AH Plus 封闭剂的反应中观察到更多的淋巴细胞和浆细胞（p < 0.05）。MTA 和 Endo CPM 封闭剂在整个实验过程中表现出与对照组相似的行为。
Endo CPM 封闭剂具有生物潜力。炎症反应的特征与 MTA 产生的特征相当。
