氨基磺酰基-1,3,4-噁二唑的合成与生物测定及其向 1,3,4-噻二唑的转化。
Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles.
机构信息
Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh 517 502, India.
出版信息
Eur J Med Chem. 2010 Sep;45(9):4246-51. doi: 10.1016/j.ejmech.2010.06.022. Epub 2010 Jun 22.
PMID:20630628
Abstract
A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The compounds are screened for antimicrobial and antioxidant activities.
摘要
一种新的噁二唑类化合物是通过用不同的羧酸酰肼处理氨磺酰基乙酸来制备的。噁二唑与硫脲相互转化为噻二唑。这些化合物被筛选用于抗菌和抗氧化活性。
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