Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Arch Pharm (Weinheim). 2013 Jul;346(7):511-20. doi: 10.1002/ardp.201300115. Epub 2013 Jun 25.
A new class of acetamidomethylsulfonyl bis heterocycles-oxazolyl-1,3,4-oxadiazoles, -thiazolyl-1,3,4-oxadiazoles, and -imidazolyl-1,3,4-oxadiazoles were synthesized from the synthetic intermediates, methyl 2-((4-aryloxazol-2-ylcarbamoyl)methylsulfonyl)acetate, methyl 2-((4-arylthiazol-2-ylcarbamoyl)methylsulfonyl)acetate, and methyl 2-((4-aryl-1H-imidazol-2-ylcarbamoyl)methylsulfonyl)acetate. All the title compounds were tested for their antioxidant activity. The oxadiazolylmethylsulfonyloxazolylacetamide displayed excellent radical-scavenging activity when compared with the standard ascorbic acid.
一类新的乙酰胺基甲基砜双杂环-恶唑基-1,3,4-恶二唑、噻唑基-1,3,4-恶二唑和咪唑基-1,3,4-恶二唑，是由合成中间体，即甲基 2-((4-芳基恶唑-2-基氨甲酰基)甲基磺酰基)乙酸酯、甲基 2-((4-芳基噻唑-2-基氨甲酰基)甲基磺酰基)乙酸酯和甲基 2-((4-芳基-1H-咪唑-2-基氨甲酰基)甲基磺酰基)乙酸酯合成而来。所有标题化合物均进行了抗氧化活性测试。与标准抗坏血酸相比，恶唑基甲基磺酰基恶唑基乙酰胺表现出极好的自由基清除活性。
