Department of Urology, Gachon University Gil Hospital, Incheon, Korea.
BJU Int. 2011 Feb;107(4):591-6. doi: 10.1111/j.1464-410X.2010.09490.x.
To investigate the relationships between the 2nd to 4th digit ratio (digit ratio) and prostate volume, prostate-specific antigen (PSA) level, and the presence of prostate cancer.
Of the men that presented with lower urinary tract symptoms (LUTS) at a single tertiary academic center, 366 men aged 40 or older with a PSA level ≤ 40 ng/mL were prospectively enrolled. Right-hand 2nd and 4th digit lengths were measured prior to the PSA determinations and transrectal ultrasonography (TRUS). Prostate volumes were measured by TRUS without information about digit length. Patients with a PSA level ≥ 3 ng/mL underwent prostate biopsy.
No relationship was found between prostate volume and digit ratio [correlation coefficient (r) = -0.038, P = 0.466]. But, significant negative correlations were found between digit ratio and PSA (r = -0.140, P = 0.007). When the patients were divided into two groups (Group A: digit ratio < 0.95, n = 184; Group B: digit ratio ≥ 0.95, n = 182), Group A had a higher mean PSA level than Group B (3.26 ± 5.54 ng/mL vs 1.89 ± 2.24 ng/mL, P = 0.002) and had significantly higher risks of prostate biopsy [odds ratio (OR) = 1.75, 95% CI = 1.07-2.84] and prostate cancer (OR = 3.22, 95% CI = 1.33-7.78).
Patients with a lower digit ratio have higher risks of prostate biopsy and prostate cancer.
研究第二至第四指长比（Digit Ratio）与前列腺体积、前列腺特异性抗原（PSA）水平以及前列腺癌之间的关系。
在一家三级学术中心，对出现下尿路症状（LUTS）的男性进行前瞻性研究，共纳入 366 名年龄在 40 岁或以上、PSA 水平≤40ng/ml 的男性。在 PSA 检测和经直肠超声（TRUS）检查前，测量右手第二和第四指的长度。通过 TRUS 测量前列腺体积，而不了解指长信息。PSA 水平≥3ng/ml 的患者进行前列腺活检。
前列腺体积与指长比之间无相关性（相关系数（r）=-0.038，P=0.466）。但指长比与 PSA 呈显著负相关（r=-0.140，P=0.007）。当患者分为两组（组 A：指长比<0.95，n=184；组 B：指长比≥0.95，n=182）时，组 A 的平均 PSA 水平高于组 B（3.26±5.54ng/ml 比 1.89±2.24ng/ml，P=0.002），且进行前列腺活检的风险显著增加（优势比（OR）=1.75，95%可信区间（CI）=1.07-2.84）和前列腺癌（OR=3.22，95%CI=1.33-7.78）。
指长比较低的患者进行前列腺活检和前列腺癌的风险更高。
