Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Brain Stimul. 2010 Jul;3(3):177-80. doi: 10.1016/j.brs.2009.08.001. Epub 2009 Sep 11.
Bupropion is associated with a dose-related increased seizure risk. This effect could correlate with a change in motor cortex excitability. Transcranial magnetic stimulation (TMS) can assess changes in motor cortical excitability by measuring resting motor threshold (RMT).
RMT was determined before and during 2 weeks concomitant administration of bupropion at two different doses (150 mg/d and 300 mg/d) in a 41-year-old woman enrolled in a study of repetitive TMS (rTMS) for the treatment of depression.
RMT was significantly lower when the patient took 300 mg/d of bupropion compared with no bupropion and 150 mg/d of bupropion. When bupropion was reduced to 150 mg, RMT returned to the premedication level.
Bupropion 300 mg/d increased cortical excitability as demonstrated by decreased RMT. This finding emphasizes the importance of assessing RMT regularly during rTMS treatment, especially in the context of new or changed doses of medications.
安非他酮与剂量相关的癫痫发作风险增加有关。这种效应可能与运动皮层兴奋性的变化相关。经颅磁刺激（TMS）可以通过测量静息运动阈值（RMT）来评估运动皮质兴奋性的变化。
在一项重复经颅磁刺激（rTMS）治疗抑郁症的研究中，我们对一名 41 岁女性在两周内同时给予两种不同剂量（150mg/d 和 300mg/d）安非他酮的情况下，在治疗前和治疗期间测定 RMT。
与未服用安非他酮和服用 150mg/d 安非他酮相比，当患者服用 300mg/d 安非他酮时，RMT 显著降低。当安非他酮减少到 150mg 时，RMT 恢复到了用药前的水平。
安非他酮 300mg/d 可通过降低 RMT 来增加皮质兴奋性。这一发现强调了在 rTMS 治疗期间定期评估 RMT 的重要性，尤其是在新的或改变药物剂量的情况下。
