Division of Cognitive Neuroscience, Department of Psychology, University of Basel Basel, Switzerland ; Psychiatric University Clinics, University of Basel Basel, Switzerland.
Division of Cognitive Neuroscience, Department of Psychology, University of Basel Basel, Switzerland.
Ann Clin Transl Neurol. 2014 Jan;1(1):69-73. doi: 10.1002/acn3.22. Epub 2013 Dec 6.
Cognitive functions, such as working memory, depend on neuronal excitability in a distributed network of cortical regions. It is not known, however, if interindividual differences in cortical excitability are related to differences in working memory performance. In the present transcranial magnetic stimulation study, which included 188 healthy young subjects, we show that participants with lower resting motor threshold, which is related to higher corticospinal excitability, had increased 2-back working memory performance. The findings may help to better understand the link between cortical excitability and cognitive functions and may also have important clinical implications with regard to conditions of altered cortical excitability.
认知功能，如工作记忆，依赖于皮质区域分布式网络中的神经元兴奋性。然而，尚不清楚皮质兴奋性的个体差异是否与工作记忆表现的差异有关。在本项包含 188 名健康年轻受试者的经颅磁刺激研究中，我们发现静息运动阈值较低（与皮质脊髓兴奋性较高相关）的参与者具有更高的 2 -back 工作记忆表现。这些发现可能有助于更好地理解皮质兴奋性与认知功能之间的联系，并且对于皮质兴奋性改变的情况也可能具有重要的临床意义。
