Kim Ho-Jun, Park Jung-Mi, Kim Jin-Ah, Ko Byeong-Pyo
Department of Oriental Rehabilitation Medicine, Dongguk University Ilsan Hospital, Korea.
J Acupunct Meridian Stud. 2008 Dec;1(2):128-38. doi: 10.1016/S2005-2901(09)60033-9.
As obesity is becoming an epidemic, diet programs, including low-calorie diets, are continuously being developed. It is generally believed that a low-calorie diet is commonly followed by a resting metabolic rate decrease and ultimate weight regain. Ephedra sinica and evodia rutaecarpa are known to have sympathomimetic and anti-obesity effects.
This study was a prospective; double-blinded, randomized and placebo-controlled clinical trial to evaluate the effects of ephedra sinica and evodia rutaecarpa on resting metabolic rate (RMR), body composition and short-term safety in obese Korean premenopausal women on a low-calorie diet.
One hundred and twenty-five otherwise healthy obese women (body mass index > or =25 kg/m(2)) were recruited and randomly assigned to three groups: ephedra group (n = 41), evodia group (n = 45) and placebo group (n = 39). Subjects were administered ephedra extract in capsules (pseudo-ephedrine 31.52 mg) or evodia extract in capsules (evodiamine 6.75 mg, rutaecarpine 0.66 mg) or placebo capsules as well as participating in a low-calorie diet for 8 weeks. Resting metabolic rate and body composition were measured at baseline, 4 and 8 weeks. Basic serum tests were performed to evaluate the short-term safety and lipid-lowering effects of the herbs.
All three groups showed significant body mass index (BMI) decreases, probably due to the low-calorie diet. Among the groups, the most prominent BMI-reducing effect was seen in the ephedra group. In RMR, no significant change in any group or significant difference among the groups was found. No significant adverse effects were observed in serum tests or in the self-questionnaire.
Ephedra combined with a low-calorie diet was effective in reducing BMI. RMR change was not compensated for by the herbal medicines tried. RMR change seemed to be affected by constitution and body composition rather than by medicine. Ephedra and evodia were proven to be safe for short-term use in the herbal form.
由于肥胖正成为一种流行病，包括低热量饮食在内的饮食方案不断被开发出来。人们普遍认为，低热量饮食通常会伴随着静息代谢率下降以及最终体重反弹。已知麻黄和吴茱萸具有拟交感神经和抗肥胖作用。
本研究是一项前瞻性、双盲、随机和安慰剂对照临床试验，旨在评估麻黄和吴茱萸对低热量饮食的肥胖韩国绝经前女性静息代谢率（RMR）、身体成分和短期安全性的影响。
招募了125名其他方面健康的肥胖女性（体重指数≥25kg/m²），并随机分为三组：麻黄组（n = 41）、吴茱萸组（n = 45）和安慰剂组（n = 39）。受试者服用胶囊形式的麻黄提取物（伪麻黄碱31.52mg）或吴茱萸提取物（吴茱萸碱6.75mg，吴茱萸次碱0.66mg）或安慰剂胶囊，并参与低热量饮食8周。在基线、第4周和第8周测量静息代谢率和身体成分。进行基本血清检测以评估草药的短期安全性和降脂效果。
所有三组的体重指数（BMI）均显著下降，这可能归因于低热量饮食。在这些组中，麻黄组的BMI降低效果最为显著。在静息代谢率方面，未发现任何组有显著变化，组间也无显著差异。血清检测或自我问卷调查中未观察到显著不良反应。
麻黄与低热量饮食相结合在降低BMI方面有效。所试验的草药未能补偿静息代谢率的变化。静息代谢率的变化似乎受体质和身体成分影响，而非药物。已证明麻黄和吴茱萸以草药形式短期使用是安全的。
