白茅、温州蜜柑和吴茱萸的一种草药提取物粉末（YY - 312）对超重成年人身体脂肪量的影响：一项为期12周的随机、双盲、安慰剂对照、平行组临床试验。
Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial.
作者信息
Cho Young-Gyu, Jung Ji-Hye, Kang Jae-Heon, Kwon Jin Soo, Yu Seung Pil, Baik Tae Gon
机构信息
Department of Family Medicine, Seoul Paik Hospital, College of Medicine, Inje University, Mareunnaero 9, Jung-gu, Seoul, 04551, Korea.
Institute for Clinical Nutrition, Inje University, Seoul, Korea.
出版信息
BMC Complement Altern Med. 2017 Jul 28;17(1):375. doi: 10.1186/s12906-017-1871-4.
BACKGROUND
YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate the efficacy and safety of YY-312 for body fat reduction in overweight adults.
METHODS
This was a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial performed in overweight Korean adults aged 19-60 years with a body mass index of 25.0-29.9 kg/m. The daily dose of YY-312 was 2400 mg (containing 1800 mg of active herbal extract and 600 mg of cyclodextrin). Primary outcomes were reductions in body fat mass (BFM) and body fat percentage (BF%) after 12 weeks. Secondary outcomes included reductions in body weight and waist circumference (WC) after 12 weeks.
RESULTS
After 12 weeks, BFM (1.6 kg vs. 0.1 kg; P = 0.023) and BF% (1.5% vs. -0.2%; P = 0.018) decreased significantly more in the YY-312 group than in the placebo group, as did body weight (2.7 kg vs. 1.0 kg; P = 0.014) and WC (2.2 cm vs. 0.8 cm; P = 0.049). All safety parameters were within normal limits; no serious adverse events occurred in either group.
CONCLUSIONS
In a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated.
TRIAL REGISTRATION
cris.nih.go.kr: ( KCT0001225 ).
背景
YY - 312是一种由白茅、温州蜜柑和吴茱萸制成的草药提取物粉末，这些草药具有促进健康的功效，包括减少体脂。我们旨在评估YY - 312对超重成年人减少体脂的疗效和安全性。
方法
这是一项为期12周的随机、双盲、安慰剂对照、平行组临床试验，在19至60岁、体重指数为25.0至29.9kg/m的超重韩国成年人中进行。YY - 312的每日剂量为2400mg（含1800mg活性草药提取物和600mg环糊精）。主要结局是12周后体脂肪量（BFM）和体脂百分比（BF%）的降低。次要结局包括12周后体重和腰围（WC）的降低。
结果
12周后，YY - 312组的BFM（1.6kg对0.1kg；P = 0.０23）和BF%（1.5%对 - 0.2%；P = 0.０18）比安慰剂组显著降低更多，体重（2.7kg对1.0kg；P = 0.０14）和WC（2.2cm对0.8cm；P = 0.０49）也是如此。所有安全参数均在正常范围内；两组均未发生严重不良事件。
结论
在一项针对超重成年人的12周临床试验中，与安慰剂相比，YY - 312能显著降低更多体脂，且安全并耐受性良好。
试验注册
cris.nih.go.kr: (KCT0001225)
Zotero 插件