College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea.
Food Chem Toxicol. 2010 Oct;48(10):2797-802. doi: 10.1016/j.fct.2010.07.009. Epub 2010 Jul 13.
Mast cell-mediated allergic symptoms are involved in many diseases, such as asthma and sinusitis. In this study, we investigated the effect of ethanol extract of fruits of Prunus persica (L) Batsch (FPP) on the mast cell-mediated allergic inflammation and studied the possible mechanism of action. FPP dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. Histamine releasing from mast cells was reduced by FPP, which was mediated by modulation of intracellular calcium. In addition, FPP attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of FPP on pro-inflammatory cytokines was nuclear factor (NF)-kappaB dependent. Our findings provide evidence that FPP inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-kappaB in these effects.
肥大细胞介导的过敏症状涉及许多疾病，如哮喘和鼻窦炎。在这项研究中，我们研究了桃（Prunus persica （L）Batsch）果实乙醇提取物（FPP）对肥大细胞介导的过敏炎症的影响，并研究了其可能的作用机制。FPP 剂量依赖性地抑制了化合物 48/80 诱导的全身性过敏反应和免疫球蛋白 E 介导的局部过敏反应。FPP 通过调节细胞内钙来减少肥大细胞释放组胺。此外，FPP 减弱了佛波醇 12-肉豆蔻酸 13-乙酸酯和钙离子载体 A23187（PMACI）刺激的人肥大细胞中促炎细胞因子的表达和分泌。FPP 对促炎细胞因子的抑制作用依赖于核因子（NF）-kappaB。我们的研究结果提供了证据，表明 FPP 抑制肥大细胞来源的过敏炎症，以及钙和 NF-kappaB 在这些作用中的参与。
