Department of Physical Therapy, China Medical University, Taichung, Taiwan.
Neurosci Lett. 2010 Sep 20;482(1):76-80. doi: 10.1016/j.neulet.2010.07.011. Epub 2010 Jul 13.
The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED(50)) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (P<0.01 for each comparison). On an equipotent basis (ED(25), ED(50), and ED(75)), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (P<0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.
本研究旨在评估维拉帕米和地尔硫卓的椎管内麻醉效果。向大鼠鞘内注射维拉帕米和地尔硫卓后，构建剂量-反应曲线。我们评估了维拉帕米或地尔硫卓与常用局麻药甲哌卡因相比的效能和持续时间。维拉帕米、地尔硫卓和甲哌卡因作为椎管内麻醉产生了剂量依赖性的局部麻醉作用。基于 50%有效剂量（ED（50）），维拉帕米的椎管内麻醉效果强于地尔硫卓或甲哌卡因（每种比较的 P<0.01）。在等效剂量（ED（25）、ED（50）和 ED（75））基础上，地尔硫卓引起的椎管内麻醉阻滞持续时间长于维拉帕米或甲哌卡因（每种比较的 P<0.01）。总之，与地尔硫卓或甲哌卡因相比，维拉帕米产生更强的脊髓阻滞作用。地尔硫卓比维拉帕米或甲哌卡因表现出更长的脊髓阻滞作用。
