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新型聚碳酸酯-聚氨酯人工髋关节垫形轴承的磨损率评估。

Wear rate evaluation of a novel polycarbonate-urethane cushion form bearing for artificial hip joints.

机构信息

Research & Development Center, Active Implants Corporation, Netanya 42505, Israel.

出版信息

Acta Biomater. 2010 Dec;6(12):4698-707. doi: 10.1016/j.actbio.2010.07.011. Epub 2010 Jul 13.

Abstract

There is growing interest in the use of compliant materials as an alternative to hard bearing materials such as polyethylene, metal and ceramics in artificial joints. Cushion form bearings based on polycarbonate-urethane (PCU) mimic the natural synovial joint more closely by promoting fluid-film lubrication. In the current study, we used a physiological simulator to evaluate the wear characteristics of a compliant PCU acetabular buffer, coupled against a cobalt-chrome femoral head. The wear rate was evaluated over 8 million cycles gravimetrically, as well as by wear particle isolation using filtration and bio-ferrography (BF). The gravimetric and BF methods showed a wear rate of 9.9-12.5mg per million cycles, whereas filtration resulted in a lower wear rate of 5.8mg per million cycles. Bio-ferrography was proven to be an effective method for the determination of wear characteristics of the PCU acetabular buffer. Specifically, it was found to be more sensitive towards the detection of wear particles compared to the conventional filtration method, and less prone to environmental fluctuations than the gravimetric method. PCU demonstrated a low particle generation rate (1-5×10⁶ particles per million cycles), with the majority (96.6%) of wear particle mass lying above the biologically active range, 0.2-10μm. Thus, PCU offers a substantial advantage over traditional bearing materials, not only in its low wear rate, but also in its osteolytic potential.

摘要

人们越来越感兴趣地使用顺应性材料作为替代硬支承材料,如聚乙烯、金属和陶瓷在人工关节。基于聚碳酸酯-聚氨酯(PCU)的垫形轴承更紧密地模拟自然的滑膜关节,通过促进流体膜润滑。在目前的研究中,我们使用生理模拟器评估顺应性 PCU 髋臼缓冲器的磨损特性,与钴铬股骨头配对。通过重量法在 800 万次循环内评估磨损率,以及通过过滤和生物铁谱学(BF)分离磨损颗粒。重量法和 BF 方法显示磨损率为每百万次循环 9.9-12.5mg,而过滤法导致每百万次循环 5.8mg 的较低磨损率。生物铁谱学被证明是一种有效的方法,用于确定 PCU 髋臼缓冲器的磨损特性。具体来说,与传统的过滤方法相比,它被发现对磨损颗粒的检测更敏感,并且比重量法更不容易受到环境波动的影响。PCU 显示出低的颗粒生成率(每百万次循环 1-5×10⁶ 个颗粒),其中大部分(96.6%)磨损颗粒质量位于生物活性范围内,0.2-10μm。因此,PCU 不仅在低磨损率方面,而且在其溶骨性潜力方面,都为传统的轴承材料提供了实质性的优势。

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