Ellison Gaewyn, Hollings Ashley L, Hackett Mark J
School of Molecular and Life Sciences, Curtin University, Perth, WA 6845, Australia.
Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.
BBA Adv. 2021 Dec 26;2:100038. doi: 10.1016/j.bbadva.2021.100038. eCollection 2022.
It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemical form ("metallome") of these metals is linked to the pathology of numerous brain diseases or disorders. Despite the known importance of metal ions for both brain health and disease, the metallome that exists within specific types of brain cells is yet to be fully characterised. The aim of this mini-review is to present an overview of the current knowledge of the metallome found within specific brain cells (oligodendrocytes, astrocytes, microglia, and neurons), as revealed by direct elemental mapping techniques. It is hoped this review will foster continued research using direct elemental mapping techniques to fully characterise the brain cell metallome.
现已充分证实，过渡金属，如铁（Fe）、铜（Cu）和锌（Zn）对健康的脑功能是必需的。尽管铁、铜和锌对大脑至关重要，但这些金属的数量、分布或化学形式（“金属组”）失衡与多种脑部疾病或障碍的病理状况相关。尽管已知金属离子对脑健康和疾病都很重要，但特定类型脑细胞内的金属组尚未得到充分表征。本小型综述的目的是概述通过直接元素映射技术揭示的特定脑细胞（少突胶质细胞、星形胶质细胞、小胶质细胞和神经元）内金属组的当前知识。希望本综述将促进使用直接元素映射技术进行持续研究，以充分表征脑细胞金属组。
