Hung Nguyen Ngoc
National Hospital of Pediatrics of Vietnam, Hanoi, Vietnam.
J Pediatr Orthop B. 2010 Nov;19(6):497-506. doi: 10.1097/BPB.0b013e32833cb8a2.
The objective of this study was to evaluate the results of drainage and continuous antibiotic irrigation of the medullary canal to mediate hematogenous osteomyelitis of the tibia in children. Data were analyzed from 376 patients (388 tibiae) treated from January 1982 to December 2004. The average age at the time of surgery was 5 years and 9 months. The diagnosis of mediate hematogenous osteomyelitis was based on clinical examination, plain radiographs, scintigraphy, ultrasound, and bacterial cultures. Treatment included two groups: (i) group I [from January 1981 to September 1984 in 108 patients (112 tibiae)] who were operated on according to traditional surgical procedure (pus drainage), (ii) group II [from October 1984 to December 2004 in 268 patients (276 tibiae)] who were operated on according to cortical bone fenestrations with continuous antibiotic irrigation. Postoperative antibiotic(s) with the intravenous antibiotic therapy were administered for 2 weeks and oral antibiotic therapy for 4 weeks. The total time of antibiotic therapy was 6 weeks. There were 152 (40.4%) female and 224 (59.6%) male patients. Unilateral involvement was the most common, with the left tibia affected in 119 (31.6%) patients, and the right in 245 (65.2%). Both tibiae were involved in 12 (3.2%) patients. The average age at the time of operation was 5 years 9 months (range: 22 days-13 years, 7 months). All patients were classified as having a mediate stage of osteomyelitis. We attained good results in 50.9% of the patients in the group I, fair results in 7.1%, and poor results in 42% with pathologic fracture in eight tibiae. In group II, there were good results in 77.9%, fair results in 21.4%, and poor results in 0.7% tibiae with the development of chronic osteomyelitis and without pathologic fracture. In conclusion, this technique is generally safe and effective. We suggest that similar management might also be applied for hematogenous osteomyelitis of femur and humerus.
本研究的目的是评估髓腔引流及持续抗生素灌洗治疗儿童胫骨血源性骨髓炎的效果。分析了1982年1月至2004年12月期间接受治疗的376例患者(388条胫骨)的数据。手术时的平均年龄为5岁9个月。血源性骨髓炎的诊断基于临床检查、X线平片、骨闪烁显像、超声及细菌培养。治疗分为两组:(i)第一组[1981年1月至1984年9月,共108例患者(112条胫骨)],按照传统手术方法(脓液引流)进行手术;(ii)第二组[1984年10月至2004年12月,共268例患者(276条胫骨)],按照皮质骨开窗并持续抗生素灌洗的方法进行手术。术后静脉应用抗生素治疗2周,口服抗生素治疗4周。抗生素治疗总时长为6周。患者中女性152例(40.4%),男性224例(59.6%)。单侧受累最为常见,左侧胫骨受累119例(31.6%),右侧胫骨受累245例(65.2%)。双侧胫骨受累12例(3.2%)。手术时的平均年龄为5岁9个月(范围:22天至13岁7个月)。所有患者均被归类为骨髓炎的中期阶段。第一组患者中,50.9%取得良好效果,7.1%取得中等效果,42%效果较差,8条胫骨出现病理性骨折。第二组中,77.9%取得良好效果,21.4%取得中等效果,0.7%效果较差,未出现慢性骨髓炎及病理性骨折。总之,该技术总体安全有效。我们建议类似的治疗方法也可应用于股骨和肱骨的血源性骨髓炎。