Demir Hacı Ahmet, Varan Ali, Akyüz Canan, Söylemezoğlu Figen, Cila Ayşenur, Büyükpamukçu Münevver
Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, Ankara, Turkey.
Childs Nerv Syst. 2011 Jan;27(1):187-92. doi: 10.1007/s00381-010-1218-7. Epub 2010 Jul 16.
Spinal seeding of primary malignant intracranial tumors via CSF is common. However, this is rare in low-grade glial tumors. Cranial leptomeningeal metastasis of primary spinal cord low-grade gliomas at diagnosis or relapse is extremely rare. Leptomeningeal metastasis of spinal cord low-grade tumors may mimic tuberculous meningitis in children. A patient with primary spinal cord low-grade neoplasm mimicked tuberculous meningitis is presented. The patient successfully treated with chemoradiotherapy. At the end of 19-month follow-up, diffuse leptomeningeal infiltration and a dural mass compatible with relapse developed. Chemoradiotherapy was started.
原发性颅内恶性肿瘤经脑脊液发生脊髓播散很常见。然而,这在低级别胶质瘤中很少见。原发性脊髓低级别胶质瘤在诊断或复发时发生颅软脑膜转移极为罕见。脊髓低级别肿瘤的软脑膜转移在儿童中可能类似结核性脑膜炎。本文报告1例表现类似结核性脑膜炎的原发性脊髓低级别肿瘤患者。该患者接受放化疗后获得成功治疗。在19个月随访结束时,出现了弥漫性软脑膜浸润和与复发相符的硬脑膜肿块。于是开始进行放化疗。