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Beyond immunosuppression: reconsidering indoleamine 2,3-dioxygenase as a pathogenic element of chronic inflammation.

作者信息

Muller Alexander J, Mandik-Nayak Laura, Prendergast George C

出版信息

Immunotherapy. 2010 May;2(3):293-7. doi: 10.2217/imt.10.22.

DOI:10.2217/imt.10.22
PMID:20635895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4096238/
Abstract
摘要

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本文引用的文献

1
Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.丙酮酸乙酯抑制吲哚胺 2,3-双加氧酶免疫治疗和肿瘤生长。
Cancer Res. 2010 Mar 1;70(5):1845-53. doi: 10.1158/0008-5472.CAN-09-3613. Epub 2010 Feb 16.
2
The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.免疫调节酶吲哚胺2,3-双加氧酶（IDO）反常地驱动B细胞介导的自身免疫。
J Immunol. 2009 Jun 15;182(12):7509-17. doi: 10.4049/jimmunol.0804328.
3
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.核因子-κB是癌症治疗的理想靶点吗？希望与困境。
Nat Rev Drug Discov. 2009 Jan;8(1):33-40. doi: 10.1038/nrd2781.
4
Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.促进肿瘤进展的慢性炎症通过诱导吲哚胺2,3-双加氧酶产生局部免疫抑制。
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17073-8. doi: 10.1073/pnas.0806173105. Epub 2008 Oct 24.
5
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.吲哚胺2,3-双加氧酶是一系列新型强效萘醌类抑制剂的抗癌靶点。
J Med Chem. 2008 Mar 27;51(6):1706-18. doi: 10.1021/jm7014155. Epub 2008 Mar 5.
6
A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase.基于天然产物的油菜素的一种关键体内抗肿瘤作用机制是抑制吲哚胺2,3-双加氧酶。
Oncogene. 2008 May 1;27(20):2851-7. doi: 10.1038/sj.onc.1210939. Epub 2007 Nov 19.
7
Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season.吲哚胺2,3-双加氧酶活性在系统性红斑狼疮患者中升高，并可预测在阳光照射季节的疾病活动。
Clin Exp Immunol. 2007 Nov;150(2):274-8. doi: 10.1111/j.1365-2249.2007.03480.x. Epub 2007 Aug 17.
8
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan.新型色氨酸分解代谢酶IDO2是抗肿瘤吲哚胺2,3-双加氧酶抑制化合物D-1-甲基色氨酸的首选生化靶点。
Cancer Res. 2007 Aug 1;67(15):7082-7. doi: 10.1158/0008-5472.CAN-07-1872.
9
Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice.在人类和小鼠中发现的一种吲哚胺2,3-双加氧酶样蛋白的特性分析。
Gene. 2007 Jul 1;396(1):203-13. doi: 10.1016/j.gene.2007.04.010. Epub 2007 Apr 18.
10
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors.用小分子抑制剂靶向肿瘤免疫耐受机制。
Nat Rev Cancer. 2006 Aug;6(8):613-25. doi: 10.1038/nrc1929.