Laboratório de Dermatologia e Imunodeficiências - LIM56, Faculdade de Medicina da Universidade de São Paulo, Instituto de Medicina Tropical - Prédio II, Av Dr Enéas de Carvalho Aguiar, 500, 3 masculine andar, 05403-05000, São Paulo, Brazil.
Immunotherapy. 2009 Jan;1(1):141-56. doi: 10.2217/1750743X.1.1.141.
This article reviews recent experimental approaches of preventive strategies regarding allergy and infections by pathogens, particularly in early childhood, by targeting maternal immunomodulation. Basic research is essential to understand maternal vaccination as a strategy to control allergic disease and bacterial and viral infections; thus, providing support for future translational research. The environmental stimuli and host genetic factors, along with maternal influences in early life when immune systems are developing and during postnatal life, are essential for the decision between tolerance induction or allergen sensitization. Maternal immunomodulation strategies should serve as a challenge when attempting to halt the spread of allergy responses and viral infections, until the innate and adaptive arms of the immune system of the neonates are competent.
本文综述了近年来通过靶向母体免疫调节来预防过敏和感染病原体的策略，特别是在儿童早期的实验方法。基础研究对于理解母体疫苗接种作为控制过敏性疾病和细菌及病毒感染的策略至关重要，为未来的转化研究提供了支持。环境刺激和宿主遗传因素，以及生命早期免疫系统发育和出生后生命期间的母体影响，对于决定诱导耐受或过敏原致敏至关重要。母体免疫调节策略应作为阻止过敏反应和病毒感染传播的挑战，直到新生儿的先天和适应性免疫系统具有功能。
