Laboratory of Dermatology and Immunodeficiencies, LIM-56, Medical School, University of Sao Paulo, Avenida Dr. Eneas de Carvalho Aguiar 500, Third Floor, 05403-000 Sao Paulo, SP, Brazil.
J Immunol Res. 2014;2014:780386. doi: 10.1155/2014/780386. Epub 2014 Jun 9.
A variety of mechanisms are involved in the regulation of offspring allergy development through maternal immunization with allergens. The passive transfer of antigens, antibodies, and cytokines, the induction of phenotypic alterations in offspring lymphocytes, and the induction of regulatory populations in offspring have been proposed, but these mechanisms remain incompletely understood. It is likely that maternal immunization could affect the intrathymic maturation of offspring TCD4+, TCD8+, γδT, nTreg, iNKT, and B lymphocytes, although there are currently no human maternal immunization protocols for the regulation of allergic responses in children. Some studies have suggested a direct interaction between the maternal immune status and the offspring intrathymic microenvironment; this interaction could influence the maturation of offspring regulatory cells and must be explored for the development of therapies to control allergy development in children.
通过过敏原母体免疫，多种机制参与了子代过敏发展的调控。抗原、抗体和细胞因子的被动转移、子代淋巴细胞表型改变的诱导，以及子代调节群体的诱导等机制已被提出，但这些机制仍不完全清楚。尽管目前尚无用于调节儿童过敏反应的人类母体免疫接种方案，但母体免疫接种可能影响子代 TCD4+、TCD8+、γδT、nTreg、iNKT 和 B 淋巴细胞的胸腺内成熟。一些研究表明，母体免疫状态与子代胸腺内微环境之间存在直接相互作用；这种相互作用可能影响子代调节细胞的成熟，必须加以探索，以开发控制儿童过敏发展的治疗方法。
