甘露糖结合凝集素与结核病易感性：荟萃分析。
Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis.
机构信息
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Melbourne, Vic., Australia.
出版信息
Clin Exp Immunol. 2010 Oct;162(1):84-90. doi: 10.1111/j.1365-2249.2010.04221.x. Epub 2010 Aug 19.
Abstract
It has been proposed that mannose-binding lectin (MBL) levels may impact upon host susceptibility to tuberculosis (TB) infection; however, evidence to date has been conflicting. We performed a literature review and meta-analysis of 17 human trials considering the effect of MBL2 genotype and/or MBL levels and TB infection. No significant association was demonstrated between MBL2 genotype and pulmonary TB infection. However, the majority of studies did not report MBL2 haplotype inclusive of promoter polymorphisms. Serum MBL levels were shown to be consistently elevated in the setting of TB infection. While this may indicate that high MBL levels protect against infection with TB, the increase was also of a degree consistent with the acute-phase reaction. This analysis suggests that the relatively poorly characterized MBL2 genotypes reported are not associated significantly with susceptibility to pulmonary TB infection, but high MBL serum levels may be.
摘要
有人提出甘露糖结合凝集素 (MBL) 水平可能影响宿主对结核病 (TB) 感染的易感性；然而，迄今为止的证据相互矛盾。我们对 17 项人类试验进行了文献回顾和荟萃分析，考虑了 MBL2 基因型和/或 MBL 水平和 TB 感染的影响。MBL2 基因型与肺结核感染之间未显示出显著相关性。然而，大多数研究没有报告包括启动子多态性在内的 MBL2 单倍型。在 TB 感染的情况下，血清 MBL 水平显示出一致升高。虽然这可能表明高 MBL 水平可预防 TB 感染，但这种增加程度也与急性期反应一致。这项分析表明，报道的相对特征不明确的 MBL2 基因型与肺结核感染的易感性没有显著关联，但高 MBL 血清水平可能有关联。
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