Biochemische Okologie und Molekulare Evolution, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Plant Biol (Stuttg). 2010 Jul 1;12(4):570-7. doi: 10.1111/j.1438-8677.2009.00317.x.
Gene duplications are regarded as one of the central mechanisms for the origin of new genes. Recent studies in plant secondary metabolism have provided several examples of genes that originated by duplication with successive diversification. In this review, the mechanisms of gene duplication are explained and several models discussed that suggest the way that gene duplicates develop into genes with new functions. Signatures of gene duplication and diversification processes are discussed using the biosynthesis of benzoxazinones and of pyrrolizidine alkaloids as examples.
基因复制被认为是新基因起源的核心机制之一。最近在植物次生代谢中的研究提供了几个由复制和连续多样化产生的基因的例子。在这篇综述中，解释了基因复制的机制，并讨论了几个模型，这些模型表明了基因复制如何发展成具有新功能的基因。使用苯并恶嗪酮和吡咯里西啶生物碱的生物合成作为例子，讨论了基因复制和多样化过程的特征。
