Kirikkale University, School of Medicine, Department of Neurosurgery, 71100 Kirikkale, Turkey.
Injury. 2010 Oct;41(10):1068-74. doi: 10.1016/j.injury.2010.05.027.
Many of the hypotheses have been suggested to explain the mechanism of the secondary effects of traumatic spinal cord injury (TSCI) as follows: ischaemia/reperfusion disability theory, free radicals theory, exitotoxicity theory, immunological destruction theory, apoptosis theory. Recently, free radicals,lipid peroxidation reactions and apoptosis theories have been much more accepted than others. In this study, possible protective effects of the alpha lipoic acid were evaluated in the traumatic spinal cord of rats.
Using a well characterised weight drop technique, spinal cord contusions were formed to 48 Wistar albino rats at thoracal 8–10 level. After alpha lipoic acid and methylprednisolone were administered intraperitoneally, the spinal cord tissues were harvested for histopathological and biochemical studies.
Histopathological examination results showed that neither methylprednisolone nor alpha lipoic acid can play an act to decrease or block the neural tissue destruction and necrosis in hyperacute and subacute stage of the TSCI in rats. Biochemical study results showed that alpha lipoic acid was much more decreased the lipid peroxidation levels than methylprednisolone in subacute stage. However, none of the agents was changed the myeloperoxidation level in subacute stage.
Alpha lipoic acid and methylprednisolone administrations did not alter the onset or degree of necrosis at the zone of the TSCI in rats. On the other hand, alpha lipoic acid is more effective than methylprednisolone treatment for the prevention of lipid peroxidation after spinal cord injury.
许多假说被提出以解释创伤性脊髓损伤（TSCI）的继发效应的机制，如下：缺血/再灌注损伤理论、自由基理论、兴奋毒性理论、免疫破坏理论、细胞凋亡理论。最近，自由基、脂质过氧化反应和细胞凋亡理论比其他理论更被接受。在这项研究中，评估了α-硫辛酸在创伤性大鼠脊髓中的可能保护作用。
使用特征明确的重物坠落技术，在胸 8-10 水平对 48 只 Wistar 白化大鼠形成脊髓挫伤。在腹腔内给予α-硫辛酸和甲泼尼龙后，采集脊髓组织进行组织病理学和生化研究。
组织病理学检查结果表明，甲泼尼龙和α-硫辛酸都不能减少或阻止大鼠 TSCI 超急性期和急性期的神经组织破坏和坏死。生化研究结果表明，在亚急性期，α-硫辛酸比甲泼尼龙更能降低脂质过氧化水平。然而，在亚急性期，没有一种药物改变髓过氧化物酶水平。
α-硫辛酸和甲泼尼龙的给药并不能改变大鼠 TSCI 区的坏死发生或程度。另一方面，α-硫辛酸在预防脊髓损伤后脂质过氧化方面比甲泼尼龙更有效。
