Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Indian J Med Res. 2012 Mar;135(3):287-96.
Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery.
脊髓损伤（SCI）由两个步骤组成，包括原发性机械损伤，随后是炎症过程和细胞凋亡。继发性损伤的特征是神经元和神经胶质细胞的进一步破坏，并导致损伤扩大，从而使瘫痪扩展到更高的节段。随着促进或预防神经元炎症和细胞凋亡的机制的确定，出现了预防和治疗神经退行性疾病的新方法。从临床角度来看，本文讨论了开发治疗药物的新靶点，这些药物有可能保护脊髓免受不可逆转的损伤并促进功能恢复。
