Chakravarty Rubel, Dash Ashutosh, Pillai M R A, Venkatesh Meera
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Appl Radiat Isot. 2010 Dec;68(12):2302-5. doi: 10.1016/j.apradiso.2010.06.022. Epub 2010 Jun 30.
High specific activity (188)Re required for nuclear medicine is mostly obtained from (188)W/(188)Re generators. As the parent radionuclide (188)W is of low specific activity (<185 GBq/g), a relatively large volume of 0.9% saline is required for the elution of (188)Re. Post-elution concentration is needed in order to increase the radioactive concentration of the eluted (188)Re. An electrochemical procedure to concentrate (188)Re suitable for the preparation of radiopharmaceuticals is developed. (188)Re eluted from an alumina generator could be concentrated approximately 100 fold, and it could be used to label DMSA and HEDP with >98% yield.
核医学所需的高比活度（188）Re大多从（188）W/（188）Re发生器获得。由于母体放射性核素（188）W的比活度较低（<185 GBq/g），洗脱（188）Re需要相对大量的0.9%生理盐水。为了提高洗脱的（188）Re的放射性浓度，需要进行洗脱后浓缩。开发了一种适用于制备放射性药物的电化学浓缩（188）Re的方法。从氧化铝发生器洗脱的（188）Re可浓缩约100倍，并且可用于标记二巯基丁二酸（DMSA）和羟基亚乙基二膦酸（HEDP），产率>98%。
