Chakravarty Rubel, Shukla Rakesh, Tyagi A K, Dash Ashutosh, Venkatesh Meera
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai-400085, India.
Appl Radiat Isot. 2010 Feb;68(2):229-38. doi: 10.1016/j.apradiso.2009.10.031. Epub 2009 Oct 25.
Nanocrystalline zirconia, a novel high capacity sorbent material was synthesized and tested for its utility in the preparation of (188)W/(188)Re generators. The structural investigation of the material was carried out using X-ray diffraction, surface area determination, FTIR and TEM micrograph analysis. Various experimental parameters were optimized to separate (188)Re from (188)W. The capacity of the material was found to be approximately 325mgW/g at the optimum pH. A chromatographic (188)W/(188)Re generator was developed using this material from which >80% of (188)Re generated could be eluted with 0.9% saline solution, with high radionuclidic, radiochemical and chemical purity and appreciably high radioactive concentration suitable for radiopharmaceutical applications.
合成了新型高容量吸附剂材料纳米晶氧化锆，并测试了其在制备（188）W/（188）Re发生器中的效用。使用X射线衍射、表面积测定、傅里叶变换红外光谱（FTIR）和透射电子显微镜（TEM）显微照片分析对该材料进行了结构研究。优化了各种实验参数以从（188）W中分离出（188）Re。发现在最佳pH值下该材料的容量约为325mgW/g。使用这种材料开发了一种色谱（188）W/（188）Re发生器，从中>80%生成的（188）Re可用0.9%盐溶液洗脱，具有高放射性核素、放射化学和化学纯度以及明显高的放射性浓度，适用于放射性药物应用。
