Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Diabetes Care. 2010 Oct;33(10):2257-9. doi: 10.2337/dc10-0770. Epub 2010 Jul 16.
Serum insulin-like growth factor (IGF)-1 may have a role in the maintenance of glucose homeostasis. We examined the association between serum IGF-1 and diabetes in a representative sample of U.S. adults.
Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥ 18 years (n = 5,511) were the subjects of the study. The main outcome was the presence of diabetes (n = 387).
Lower serum IGF-1 levels were positively associated with diabetes after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, BMI, hypertension, glomerular filtration rate, and serum cholesterol. Compared with quartile 4 of IGF-1 (referent), the odds ratio (OR) of diabetes associated with quartile 1 was OR 2.16 (95% CI 1.24-3.76); P-trend = 0.002. However, the observed association between IGF-1 and diabetes was present only in those < 65 years of age (OR = 3.05; P-trend = 0.006) and disappeared in those ≥ 65 years of age (OR = 0.51; P-trend = 0.18); P-interaction = 0.0056.
Low IGF-1 levels are associated with diabetes among young subjects.
血清胰岛素样生长因子（IGF-1）可能在维持葡萄糖内稳态方面发挥作用。我们在美国成年人的代表性样本中研究了血清 IGF-1 与糖尿病之间的关系。
本研究的对象为年龄≥18 岁的第三次国家健康和营养检查调查（NHANES III）参与者（n=5511）。主要结局是糖尿病的存在（n=387）。
在调整年龄、性别、种族/民族、教育、吸烟、饮酒、BMI、高血压、肾小球滤过率和血清胆固醇后，较低的血清 IGF-1 水平与糖尿病呈正相关。与 IGF-1 四分位 4 相比（参照），IGF-1 四分位 1 相关的糖尿病比值比（OR）为 2.16（95%CI 1.24-3.76）；P 趋势=0.002。然而，在<65 岁的人群中观察到 IGF-1 与糖尿病之间的关联（OR=3.05；P 趋势=0.006），而在≥65 岁的人群中这种关联消失（OR=0.51；P 趋势=0.18）；P 交互=0.0056。
低 IGF-1 水平与年轻人群的糖尿病有关。
