Blaineau C, Gisslebrecht S, Piatier D, Hurot M A, Levy J P
Clin Exp Immunol. 1978 Feb;31(2):276-80.
Swan mice are characterized by various autoimmune disorders and the Swan disease resembles that of (NZB X NZW)F1 hybrids. A virological study of these animals shows that: (a) they do not produce xenotropic type C viruses at a detectable level; (b) old Swan mice can produce ecotropic type C virus but at a low level; and (c) this virus production and the appearance of antinuclear antibodies are dissociated in some mice. These results do not support the role of xenotropic type C viruses in murine autoimmune pathology. A possible role of ecotropic type C viruses cannot be definitely excluded, but appears unlikely.
斯旺小鼠具有多种自身免疫性疾病的特征,且斯旺病与(新西兰黑鼠×新西兰白鼠)F1杂交种的疾病相似。对这些动物的病毒学研究表明:(a)它们在可检测水平上不产生嗜异性C型病毒;(b)老龄斯旺小鼠可产生嗜亲性C型病毒,但水平较低;(c)在一些小鼠中,这种病毒产生与抗核抗体的出现不相关。这些结果不支持嗜异性C型病毒在小鼠自身免疫病理中的作用。嗜亲性C型病毒的可能作用不能被明确排除,但似乎不太可能。