Saenger P, Rifkind A B, Pareira J
Clin Pharmacol Ther. 1978 Jun;23(6):692-6. doi: 10.1002/cpt1978236692.
Administration of dexamethasone and infusion of adrenocorticotropic hormone (ACTH) to children for periods up to 4 days did not alter the half-life, apparent volume of distribution, or metabolic clearance rate of antipyrine, a drug principally metabolized by the mixed-function oxidase system of the liver. We conclude that the short-term administration of glucocorticoids and ACTH with ensuing stimulation of endogenous glucocorticoid production is unlikely to produce clinically significant changes in the rate of drug metabolism.
给儿童使用地塞米松并输注促肾上腺皮质激素（ACTH）长达4天，并未改变安替比林的半衰期、表观分布容积或代谢清除率，安替比林是一种主要由肝脏混合功能氧化酶系统代谢的药物。我们得出结论，短期给予糖皮质激素和ACTH并随之刺激内源性糖皮质激素的产生，不太可能在药物代谢速率上产生具有临床意义的变化。
