Neuropsychology Unit, Spedali Civili of Brescia, Brescia, Italy.
Neurol Sci. 2010 Nov;31(Suppl 2):S271-4. doi: 10.1007/s10072-010-0373-7.
Neuropsychological impairment affects 40-65% of multiple sclerosis patients, mainly involving speed in information processing, attention, executive functions and memory. Deterioration occurs over time independently from disability and seems to correlate particularly with magnetic resonance imaging (MRI) atrophy measures. Studies on therapies effective in controlling cognitive impairment are scanty. We found that intensive and specific training of attention, information processing and executive functions is significantly effective in ameliorating both neuropsychological treated functions and in reducing depression. Preliminary functional MRI data suggest that possible neural correlates of this neuropsychological training could be an exercise-induced activation of prefrontal and cingulate cortices.
神经心理学损伤影响 40-65%的多发性硬化症患者，主要涉及信息处理速度、注意力、执行功能和记忆。随着时间的推移，这种损伤会独立于残疾而发生，似乎与磁共振成像（MRI）萎缩测量特别相关。关于对认知损伤有控制作用的治疗方法的研究很少。我们发现，注意力、信息处理和执行功能的强化和专门训练对改善神经心理学治疗功能和减轻抑郁有显著效果。初步的功能性磁共振成像数据表明，这种神经心理学训练的可能神经相关性可能是前额叶和扣带回皮质的运动诱导激活。
